Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver
Our spatial multi-omics approach suggests cell type-specific mechanisms of fibrogenesis involving sphingolipid metabolism. Importantly, sphingolipid metabolic pathways are modifiable targets, which may have potential as an anti-fibrotic therapeutic strategy.
Authors
- David Carling (ORCID: https://orcid.org/0000-0002-2316-1830)
- Fiona Oakley (ORCID: https://orcid.org/0000-0001-8692-1836)
- Jack Leslie (ORCID: https://orcid.org/0000-0001-6443-2396)
- Mark R. Thursz (ORCID: https://orcid.org/0000-0002-8218-192X)
- Inês Cebola (ORCID: https://orcid.org/0000-0003-3528-4982)
- Stuart Robinson (ORCID: https://orcid.org/0000-0003-2623-094X)
- Jeremy French (ORCID: https://orcid.org/0000-0002-3383-6985)
- Hannah Maude (ORCID: https://orcid.org/0000-0002-7593-4516)
- Wasfi Alrawashdeh
- Robert Goldin (ORCID: https://orcid.org/0000-0001-5184-4519)
- Matthew Hoare (ORCID: https://orcid.org/0000-0001-5990-9604)
- Aleksandra Gruevska (ORCID: https://orcid.org/0000-0003-4411-829X)
- John Moir (ORCID: https://orcid.org/0000-0002-3161-4713)
- Scott E. Johnson (ORCID: https://orcid.org/0000-0002-6925-5373)
- Niloufar Safinia (ORCID: https://orcid.org/0000-0002-8885-1082)
- Roberta Forlano (ORCID: https://orcid.org/0000-0003-4746-7065)
- Joram M. Posma (ORCID: https://orcid.org/0000-0002-4971-9003)
- Laura Evangelista (ORCID: https://orcid.org/0000-0002-5955-9488)
- Derek A. Mann (ORCID: https://orcid.org/0000-0003-0950-243X)
- Pinelopi Manousou (ORCID: https://orcid.org/0000-0002-5363-1565)
- Amy Collins (ORCID: https://orcid.org/0000-0003-3619-2588)
- Zoe Hall (ORCID: https://orcid.org/0000-0002-1434-8329)
- Rohan Thakkar
- Steven White
- Eleanor Sabey
Institutions
- King's College London (GB)
- University of Cambridge (GB)
- Newcastle College (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Cancer Research UK Cambridge Center (GB)
- MRC London Institute of Medical Sciences (GB)
- Imperial College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Metabolism
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.metabol.2025.156237
- Citations
- 13
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.60