Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver

Our spatial multi-omics approach suggests cell type-specific mechanisms of fibrogenesis involving sphingolipid metabolism. Importantly, sphingolipid metabolic pathways are modifiable targets, which may have potential as an anti-fibrotic therapeutic strategy.

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Publication Details

Journal
Metabolism
Published
2025-03-22
DOI
https://doi.org/10.1016/j.metabol.2025.156237
Citations
13
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
17.60
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article

Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver

David Carling, Fiona Oakley, Jack Leslie, Mark R. Thursz et al.
13 citations
Metabolism
Liver Disease Diagnosis and Treatment
17.60
article

Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver

David Carling, Fiona Oakley, Jack Leslie, Mark R. Thursz, Inês Cebola, Stuart Robinson, Jeremy French, Hannah Maude, Wasfi Alrawashdeh, Robert Goldin, Matthew Hoare, Aleksandra Gruevska, John Moir, Scott E. Johnson, Niloufar Safinia, Roberta Forlano, Joram M. Posma, Laura Evangelista, Derek A. Mann, Pinelopi Manousou, Amy Collins, Zoe Hall, Rohan Thakkar, Steven White, Eleanor Sabey
article en
13 citations

Abstract

Our spatial multi-omics approach suggests cell type-specific mechanisms of fibrogenesis involving sphingolipid metabolism. Importantly, sphingolipid metabolic pathways are modifiable targets, which may have potential as an anti-fibrotic therapeutic strategy.

MetabolismVol. 168
King's College London (GB), University of Cambridge (GB), Newcastle College (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Cancer Research UK Cambridge Center (GB), MRC London Institute of Medical Sciences (GB), Imperial College London (GB), Newcastle University (GB)
Zero hunger
Openalex Percentile: Top 1%
Liver Disease Diagnosis and Treatment
17.60
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