Defining the recommended gray zone in O6-methylguanine-DNA methyltransferase promoter methylation pyrosequencing reporting: A robust, translatable method to implement new EANO guidelines
We have developed a translatable method to identify the optimal MGMT gray zone from pyrosequencing data in line with recent EANO guidelines, to enhance clinical decision-making.
Authors
- Sara J. Walker (ORCID: https://orcid.org/0000-0003-2180-1635)
- Jack Wildman
- Laura Yarram-Smith (ORCID: https://orcid.org/0000-0002-8857-4935)
- Ed Whittaker (ORCID: https://orcid.org/0000-0001-6394-0401)
- George J. Doyle
- Kathreena M. Kurian (ORCID: https://orcid.org/0000-0003-0303-3716)
- Claire Faulkner
- Paul White (ORCID: https://orcid.org/0000-0002-7503-9896)
- Polly Taylor
- G. Cruickshank
- Claire McKeeve
Institutions
- North Bristol NHS Trust (GB)
- University of the West of England (GB)
- NHS Greater Glasgow and Clyde (GB)
- Beatson West of Scotland Cancer Centre (GB)
- University of Bristol (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf061
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00