A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma
These findings suggest the opportunity for patient stratification and the potential for more durable antitumor immune responses in future clinical trials of this multimodal standard of care and combined immunotherapy regimen. ClinicalTrials.gov identifier: NCT03576612.
Authors
- Xiaobu Ye (ORCID: https://orcid.org/0009-0005-5356-4840)
- Louisa Little (ORCID: https://orcid.org/0000-0002-0083-7279)
- Joy Fisher (ORCID: https://orcid.org/0009-0004-5941-466X)
- Stephen Bagley (ORCID: https://orcid.org/0000-0002-7117-0539)
- Mina Pichavant
- Sean Lawler (ORCID: https://orcid.org/0000-0002-1633-2339)
- Glenn Jay Lesser (ORCID: https://orcid.org/0009-0003-5471-8907)
- Stuart A. Grossman (ORCID: https://orcid.org/0000-0002-3726-7679)
- Garrett Nichols
- Arati Desai (ORCID: https://orcid.org/0000-0002-4849-4703)
- Pierpaolo Peruzzi (ORCID: https://orcid.org/0000-0001-5034-2963)
- Frank S. Lieberman (ORCID: https://orcid.org/0000-0003-2577-3336)
- Andrew J. Gentles (ORCID: https://orcid.org/0000-0002-0941-9858)
- Diane M. Del Valle (ORCID: https://orcid.org/0000-0001-6983-5362)
- Chandana Kakani
- Patrick Y. Wen (ORCID: https://orcid.org/0000-0002-0774-7700)
- Dzifa Y. Duose (ORCID: https://orcid.org/0000-0002-6763-9736)
- Elad Sharon (ORCID: https://orcid.org/0000-0002-0044-9719)
- Roy E. Strowd (ORCID: https://orcid.org/0000-0001-6651-5267)
- Dan Triggs
- Christine Camacho (ORCID: https://orcid.org/0000-0002-5013-3093)
- Tobias Walbert (ORCID: https://orcid.org/0000-0003-0667-8106)
- Ignacio I. Wistuba (ORCID: https://orcid.org/0000-0003-3365-6340)
- Gheath Alatrash (ORCID: https://orcid.org/0000-0002-7648-4377)
- Edgar Gonzalez‐Kozlova (ORCID: https://orcid.org/0000-0002-6948-0626)
- Peixin Jiang (ORCID: https://orcid.org/0000-0002-9249-7813)
- Alex Kong
- Megan Mantica (ORCID: https://orcid.org/0000-0002-6107-6696)
- E. Antonio Chiocca (ORCID: https://orcid.org/0000-0001-5183-1670)
- Deanna L. Lane (ORCID: https://orcid.org/0000-0001-8221-4333)
- Michal O. Nowicki (ORCID: https://orcid.org/0000-0002-5807-0007)
- Steven Brem (ORCID: https://orcid.org/0000-0002-5803-8920)
- Sean C. Bendall (ORCID: https://orcid.org/0000-0003-1341-2453)
- Cara Haymaker (ORCID: https://orcid.org/0000-0002-1317-9287)
- Laura K. Aguilar (ORCID: https://orcid.org/0000-0002-3473-0330)
- Adrian W. Laxton (ORCID: https://orcid.org/0000-0002-4631-5476)
- Seunghee Kim‐Schulze (ORCID: https://orcid.org/0000-0003-0192-4400)
- Lenika Lopez
- Jan Drappatz
- Jessica Dwyer (ORCID: https://orcid.org/0000-0002-0537-7654)
- Stephen B. Tatter (ORCID: https://orcid.org/0000-0002-1063-0431)
- P. Andrew Futreal (ORCID: https://orcid.org/0000-0001-8663-2671)
- Holden T. Maecker (ORCID: https://orcid.org/0000-0003-0795-9946)
- Sacha Gnjatic (ORCID: https://orcid.org/0000-0001-5643-9520)
- Francesca Barone (ORCID: https://orcid.org/0000-0002-5287-9614)
- Caroline Duault (ORCID: https://orcid.org/0000-0003-2742-1668)
- Mohammed Rafiqul Islam (ORCID: https://orcid.org/0000-0002-2800-5044)
- Alexandre Reuben (ORCID: https://orcid.org/0000-0003-4510-0382)
- Julia Mendoza‐Pérez (ORCID: https://orcid.org/0000-0002-4019-0633)
- Ian Lee (ORCID: https://orcid.org/0000-0001-6057-7176)
- Andrea G. Manzanera
- James P. Snyder
- Paul P. Tak
- Estuardo Aguilar-Córdova
Institutions
- Brigham and Women's Hospital (US)
- Mount Sinai Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- Henry Ford Health System (US)
- Brown University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Bayview Medical Center (US)
- University Medical Center (US)
- Henry Ford Hospital (US)
- Mount Sinai Medical Center (US)
- Mount Sinai Hospital (US)
- Center for Neuro-Oncology (US)
- Dana-Farber Cancer Institute (US)
- Translational Therapeutics (United States) (US)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
- Celldex Therapeutics (United States) (US)
- Pediatric Brain Tumor Foundation (US)
- Wake Forest University (US)
- Mass General Brigham (US)
- University of Pennsylvania (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1093/neuonc/noaf079
- Citations
- 4
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.50