Targeting polyunsaturated fatty acids desaturase FADS1 inhibits renal cancer growth via ATF3-mediated ER stress response
Our findings suggest that PUFA desaturation is crucial for rescuing cancer cells from persistent ER stress, supporting FADS1 as a new therapeutic target.
Authors
- Nivisa Vakeesan (ORCID: https://orcid.org/0009-0006-6481-7425)
- Zheyun Peng (ORCID: https://orcid.org/0000-0002-6417-8778)
- Kezhong Zhang (ORCID: https://orcid.org/0000-0002-6062-235X)
- Gioia Heravi
- Jing Li (ORCID: https://orcid.org/0000-0002-9924-1386)
- Robert S. Chapkin (ORCID: https://orcid.org/0000-0002-6515-3898)
- Mackenzie K. Herroon (ORCID: https://orcid.org/0000-0001-6565-9074)
- Yang-Yi Fan (ORCID: https://orcid.org/0000-0002-2912-511X)
- Wanqing Liu (ORCID: https://orcid.org/0009-0001-7836-6489)
- Izabela Podgorski (ORCID: https://orcid.org/0000-0003-0026-8456)
- Alexis Wilson
- Yang Jiang (ORCID: https://orcid.org/0000-0001-5934-1537)
- Tao Li (ORCID: https://orcid.org/0000-0003-1531-358X)
- Zhenjie Liu (ORCID: https://orcid.org/0000-0001-6118-7882)
Institutions
- Eugene Applebaum College of Pharmacy and Health Sciences (US)
- Wayne State University (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Texas A&M University (US)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.biopha.2025.118006
- Citations
- 4
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 4.61