Clinical Outcomes for Patients With Ulcerative Colitis in Cases of Withdrawal and Resumption of Janus Kinase Inhibitors: Multicenter Cohort Study
To our knowledge, this is the first real-world study to evaluate the effects of JAKi discontinuation on the outcomes for patients with UC. JAKi discontinuation in patients in remission was associated with a high relapse risk. JAKi retreatment was highly effective in patients who experienced relapse after treatment discontinuation, providing valuable evidence for managing treatment interruption.
Authors
- Makoto Naganuma (ORCID: https://orcid.org/0000-0002-4244-3243)
- Yasuki Sano (ORCID: https://orcid.org/0009-0004-1217-3790)
- Naoto Yagi (ORCID: https://orcid.org/0000-0003-1792-2733)
- Yusuke Honzawa (ORCID: https://orcid.org/0000-0002-9601-4065)
- Norimasa Fukata (ORCID: https://orcid.org/0000-0001-9268-3299)
- Yuka Ito (ORCID: https://orcid.org/0009-0001-6327-5322)
Institutions
- Kansai Medical University (JP)
Publication Details
- Journal
- Crohn s & Colitis 360
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1093/crocol/otaf020
- Citations
- 4
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 7.27