Neuropathic pain impairs sleep architecture, non-rapid eye movement sleep, and reticular thalamic neuronal activity
Neuropathic pain is characterized by disrupted sleep architecture, reduced NREMS, and heightened RTN neuronal firing activity with partial compensation of burst activity. Given that RTN burst activity is essential for optimal NREMS, its disruption may contribute to NP-induced sleep impairments. These findings suggest that altered EEG/EMG signals, alongside dysregulated RTN neuronal activity, may serve as potential brain markers for NP-related insomnia.
Authors
- Gabriella Gobbi (ORCID: https://orcid.org/0000-0003-4124-9825)
- Anahita Oveisi
- Stefano Comai (ORCID: https://orcid.org/0000-0002-5686-7194)
- Qianzi He (ORCID: https://orcid.org/0000-0002-4607-166X)
- Maria Luisa Vigano
- Martha López-Canul
- Antonio Farina (ORCID: https://orcid.org/0000-0002-6862-1810)
Institutions
- University of Padua (IT)
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1093/ijnp/pyaf017
- Citations
- 2
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Università degli Studi di Padova
- Mitacs