Cell death pathway regulation by fatty acid metabolism-related genes in neuroblastoma: a multi-omics analysis identifying CHD5 as a novel biomarker

The developed fatty acid metabolism prognostic risk model underscores the significance of fatty acids in neuroblastoma prognosis and immune landscape, thereby facilitating the optimization of chemotherapy and immunotherapy strategies for this disease. The comprehensive analysis of cell death pathways revealed distinct regulatory mechanisms of signature genes, particularly highlighting TP63's central role in coordinating multiple cell death processes. CHD5, as an identified gene inhibiting the proliferation, invasion and metastasis of neuroblastoma cells, serves as a novel tumor biomarker.