m6A-induced DEAD-box RNA helicase 21 enhances lipid metabolism via 3‑hydroxy-3-methylglutaryl-CoA synthases 1 in colorectal cancer
Our study demonstrates that the YTHDF1/DDX21/HMGCS1 axis promotes CRC progression via regulating lipid metabolism and DDX21 might be a promising target for CRC therapy.
Authors
- Anjia Han (ORCID: https://orcid.org/0000-0003-3357-5348)
- Lin Chen (ORCID: https://orcid.org/0009-0005-1741-0975)
- Huabin Gao
- Fenfen Zhang
- Shuai Zheng (ORCID: https://orcid.org/0000-0002-9143-4909)
- Yongyu Chen (ORCID: https://orcid.org/0000-0002-2774-374X)
- Yuting Wang (ORCID: https://orcid.org/0000-0002-1443-2643)
- Hui Li
- Huijuan Shi (ORCID: https://orcid.org/0000-0002-5325-9732)
- Jiangtao Liang (ORCID: https://orcid.org/0000-0002-3530-6347)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.tranon.2025.102373
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province