Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the <scp>TRACK</scp>‐<scp>FA</scp> Study
Our findings provide strong imaging evidence of impaired development of spinal cord and superior cerebellar peduncles during childhood in Friedreich ataxia and open the way for the use of neuroimaging biomarkers in clinical trials. ANN NEUROL 2025;98:386-397.
Authors
- Imis Dogan (ORCID: https://orcid.org/0000-0002-6632-197X)
- Manuela Corti (ORCID: https://orcid.org/0000-0002-6391-4139)
- Nellie Georgiou‐Karistianis (ORCID: https://orcid.org/0000-0003-0718-6760)
- Marina Papoutsi (ORCID: https://orcid.org/0000-0003-0971-8361)
- Michelle Lax
- Marcondes C. França (ORCID: https://orcid.org/0000-0003-0898-2419)
- David R. Lynch (ORCID: https://orcid.org/0000-0001-7168-214X)
- William Gaetz (ORCID: https://orcid.org/0000-0003-1018-9559)
- Martin Bruce Delatycki (ORCID: https://orcid.org/0000-0002-8769-2569)
- Pierre‐Gilles Henry (ORCID: https://orcid.org/0000-0002-8270-1956)
- Sandro Romanzetti (ORCID: https://orcid.org/0000-0001-8519-1309)
- Jörg B. Schulz (ORCID: https://orcid.org/0000-0002-8903-0593)
- James M. Joers (ORCID: https://orcid.org/0000-0002-8444-2185)
- Alberto Martínez (ORCID: https://orcid.org/0000-0001-7160-0853)
- Anthony S. Gabay (ORCID: https://orcid.org/0000-0002-6946-1046)
- Timothy P. L. Roberts (ORCID: https://orcid.org/0000-0001-7320-4870)
- Kathrin Reetz (ORCID: https://orcid.org/0000-0002-9730-9228)
- Helena Bujalka (ORCID: https://orcid.org/0000-0003-0692-5752)
- Isaac Adanyeguh (ORCID: https://orcid.org/0000-0003-1402-5877)
- Eric F. Lock (ORCID: https://orcid.org/0000-0003-4663-2356)
- Ian H. Harding (ORCID: https://orcid.org/0000-0002-6843-9592)
- Thiago Junqueira Ribeiro de Rezende (ORCID: https://orcid.org/0000-0001-8453-0313)
- Thomas H. Mareci (ORCID: https://orcid.org/0000-0003-4700-2364)
- Christophe Lenglet (ORCID: https://orcid.org/0000-0003-4646-3185)
- Richard G. Parker
- Susmita Saha (ORCID: https://orcid.org/0000-0002-3224-4988)
- Massimo Pandolfo (ORCID: https://orcid.org/0000-0001-5230-5787)
- Veena G. Supramaniam
- Dinesh K. Deelchand (ORCID: https://orcid.org/0000-0003-4266-4780)
- Louise A. Corben (ORCID: https://orcid.org/0000-0001-8767-4582)
- David A. Rudko (ORCID: https://orcid.org/0000-0002-1299-954X)
- S. H. Subramony (ORCID: https://orcid.org/0000-0002-8052-9240)
- Jiakun Li (ORCID: https://orcid.org/0000-0003-1487-4967)
- Jennifer Farmer
Institutions
- University of Minnesota (US)
- Children's Hospital of Philadelphia (US)
- The University of Melbourne (AU)
- Forschungszentrum Jülich (DE)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- QIMR Berghofer Medical Research Institute (AU)
- University of Florida (US)
- Ixico (United Kingdom) (GB)
- Victorian Clinical Genetics Services (AU)
- Jülich Aachen Research Alliance (DE)
- Friedreich's Ataxia Research Alliance (US)
- Advanced Imaging Research (United States) (US)
- Murdoch Children's Research Institute (AU)
- Resonance Research (United States) (US)
- McGill University (CA)
- Monash University (AU)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1002/ana.27237
- Citations
- 5
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- Friedreich's Ataxia Research Alliance
- PTC Therapeutics
- AveXis
- IXICO