Patterns of disease dissemination and survival in patients with synchronous and metachronous metastatic pancreatic adenocarcinoma: Nationwide population-based study
This nationwide population-based study reveals that metachronous-mPAC less commonly presents with liver metastases and more often metastasizes to lung, peritoneum or other atypical sites compared to synchronous-mPAC. These distinct metastatic patterns and their differences in survival may help enhance the prognostic estimation for individual patients from the detection of metastatic disease and warrants further research into the biology underlying metastasis development.
Authors
- Liselot Valkenburg‐van Iersel (ORCID: https://orcid.org/0000-0003-2925-9908)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Stefan A.W. Bouwense (ORCID: https://orcid.org/0000-0002-7600-9429)
- Judith de Vos‐Geelen (ORCID: https://orcid.org/0000-0003-2578-1766)
- Hanneke W.M. van Laarhoven (ORCID: https://orcid.org/0000-0003-1274-5643)
- Merlijn U.J.E. Graus (ORCID: https://orcid.org/0000-0002-3645-1458)
- Vincent Erwin de Meijer (ORCID: https://orcid.org/0000-0002-7900-5917)
- Evelien J.M. de Jong (ORCID: https://orcid.org/0000-0002-8590-2518)
- Martijn W.J. Stommel (ORCID: https://orcid.org/0000-0002-4257-5254)
- Lois A. Daamen (ORCID: https://orcid.org/0000-0001-9227-7178)
- I Quintus Molenaar
- Ignace H. J. T. de Hingh (ORCID: https://orcid.org/0000-0003-3491-4268)
- Lydia G. van der Geest (ORCID: https://orcid.org/0000-0003-1637-5520)
- Johanna W. Wilmink (ORCID: https://orcid.org/0000-0002-1677-1278)
- Aniek E. van Diepen (ORCID: https://orcid.org/0009-0007-0192-5354)
- Kim Josemanders
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Dutch Cancer Society (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Netherlands Comprehensive Cancer Organisation (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.ejca.2025.115385
- Citations
- 5
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23