Implications of Mutant SOD1 on RNA Processing and Interferon Responses in Amyotrophic Lateral Sclerosis: Omics Data Analysis
We revealed that mtSOD1 interacted with nuclear proteins and specific DNA segments and that RNA expression was notably altered when mouse Sod1 and mtSOD1 were silenced. These interactions could play a pivotal role in motor neuron degeneration.
Authors
- Naoto Honda (ORCID: https://orcid.org/0000-0003-1588-9853)
- Ritsuko Hanajima
- Yasuhiro Watanabe (ORCID: https://orcid.org/0000-0002-1716-439X)
- Hiroki Honda (ORCID: https://orcid.org/0000-0002-8972-4093)
- Haruo Fukuhara
- Mika Uemoto
Institutions
- Tottori University Hospital (JP)
- Tottori University (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-03-23
- DOI
- https://doi.org/10.7759/cureus.81045
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78