In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach
This study demonstrated that CLNPs and Ce-6-mediated PDT can modulate several key immunosuppressive factors and the miR-30a-5p/MALAT1 axis in TNBC cells. These findings provide a rationale for further in-vivo investigation of this multimodal therapeutic strategy.
Authors
- R.A. Youness (ORCID: https://orcid.org/0000-0001-6268-7942)
- Mohammad Abdel‐Halim (ORCID: https://orcid.org/0000-0003-1326-4219)
- Asmaa Ramzy (ORCID: https://orcid.org/0000-0002-8618-970X)
- Aya Sebak (ORCID: https://orcid.org/0000-0001-9281-9184)
- Noha Mousaad Elemam (ORCID: https://orcid.org/0000-0002-3586-6731)
- Samar Mansour (ORCID: https://orcid.org/0000-0002-3033-164X)
- Tamer Manie
Institutions
- Cairo University (EG)
- University of Sharjah (AE)
- German University in Cairo (EG)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.tranon.2025.102365
- Citations
- 5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.68