Effect of repeated bolus and continuous doxorubicin administration on bone and soft tissue concentrations– a randomized study evaluated in a tumour-free porcine model
Low mean tissue doxorubicin concentrations and similar pharmacokinetic profiles were found between the bolus and continuous infusion groups. Thus, similar anti-neoplastic efficacy is to be expected with both administration types.
Authors
- Mats Bue (ORCID: https://orcid.org/0000-0001-7215-8323)
- Pelle Hanberg (ORCID: https://orcid.org/0000-0002-6845-1874)
- Hans Christian Rasmussen (ORCID: https://orcid.org/0000-0001-9101-9302)
- Elisabeth Krogsgaard Petersen (ORCID: https://orcid.org/0000-0002-5164-5197)
- Andrea René Jørgensen (ORCID: https://orcid.org/0000-0001-6334-3164)
- Christina Harlev (ORCID: https://orcid.org/0000-0001-7255-9557)
- Maiken Stilling (ORCID: https://orcid.org/0000-0002-4530-2075)
- Jakob Hansen (ORCID: https://orcid.org/0000-0002-4115-2858)
- Thomas Baad‐Hansen (ORCID: https://orcid.org/0000-0003-4826-8412)
- Akmal Safwat (ORCID: https://orcid.org/0000-0002-6020-2320)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Cancer Chemotherapy and Pharmacology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1007/s00280-025-04768-7
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aarhus Universitetshospital