Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity
These findings suggest that the accumulation of PHF-tau within astrocytes drives changes in mitochondrial biogenesis, which may influence synaptic regulation. This astrocyte-mediated adaptation to tauopathy highlights the potential role of astrocytes in modulating synaptic dynamics in response to tau stress, opening avenues for therapeutic strategies aimed at astrocytic mechanisms in the context of neurodegenerative diseases.
Authors
- Luc Nwamekang Belinga (ORCID: https://orcid.org/0009-0001-9286-1144)
- Pierre Marquet (ORCID: https://orcid.org/0000-0001-7698-0760)
- Aatmika Barve (ORCID: https://orcid.org/0000-0003-2331-5825)
- Yvan Varisco
- Kevin Richetin (ORCID: https://orcid.org/0000-0001-7859-9517)
- Paola Bezzi (ORCID: https://orcid.org/0000-0002-8279-3600)
- Nicolas Preitner
- Valentin Zufferey (ORCID: https://orcid.org/0009-0005-3393-9246)
- Enea Parietti
- Francesca Capotosti (ORCID: https://orcid.org/0000-0003-2819-3206)
- Nicole Déglon (ORCID: https://orcid.org/0000-0003-4475-9476)
- Kerstin Fabbri
- Audrey Bringaud
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- AC Immune (Switzerland) (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1186/s40035-025-00474-9
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Novartis Foundation
- Lawson Foundation
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois
- Stiftung Synapsis - Alzheimer Forschung Schweiz AFS
- Novartis Institutes for BioMedical Research