Risk of Proton Pump Inhibitor (PPI)-Induced Galactorrhea: An Uncommon Adverse Effect of a Common Drug

Galactorrhea is a rare and atypical adverse effect associated with the use of proton pump inhibitors (PPIs). They are widely used in the management of acid-related disorders and have been proven to be effective. However, like all pharmacological therapies, PPI use is accompanied by a range of adverse effects. This case report details a 27-year-old female individual with no significant medical history who presented with galactorrhea. Upon further investigation, PPI-induced galactorrhea was confirmed and discontinuation of the medication resulted in the resolution of the condition. Complex interactions between the drug, various enzymes, and receptors have been postulated as potential mechanisms underlying the development of this condition. Chronic kidney disease has also been shown to augment the development of PPI-induced galactorrhea. Further research around the mechanism driving PPI-induced galactorrhea in patients is necessary to better enable healthcare professionals to provide accurate information concerning the side effect profile of PPIs and educate patients on informed decision-making regarding PPI therapy.