Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids and their neuroprotective activities of against CORT-induced apoptosis of PC12 from the <i>Schisandra chinensis</i> leaves and stems
Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids (SNTs), Wuweizinortriters A and B (1-2) were successfully isolated from the ethanol extracts of the leaves and stems of <i>Schisandra chinensis.</i>, the determination of their structures was achieved by using NMR, MS, UV, and carbon spectrum calculation. Wuweizinortriters A and B (25 μM) moderately protected PC12 cells from CORT-induced apoptosis, with the viability increasing by 18.02% and 20.33% respectively, compared to the model group.
Authors
- Yong-Cheng Yang (ORCID: https://orcid.org/0000-0001-5499-5339)
- Yongguo Li (ORCID: https://orcid.org/0000-0003-4854-9118)
- An‐Hua Wang (ORCID: https://orcid.org/0000-0002-8615-3424)
- Jingming Jia (ORCID: https://orcid.org/0009-0002-0519-0854)
- Jian Li (ORCID: https://orcid.org/0000-0002-7521-8798)
Institutions
- Shenyang Pharmaceutical University (CN)
- Dali University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1080/14786419.2025.2481609
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.00