Nickel Selenide‐Loaded <scp>PANI</scp>/<scp>PEO</scp> Fibers for Boosted Wound Healing Response in Rabbits

ABSTRACT Wound healing is a dynamic biological process that leads to the repair of damaged body tissues and restores their ability to function as protective barriers. There are several approaches to handling and treating skin wounds; however, new and efficient procedures must be developed to cope with the inadequacies of the current methods, such as longer recovery time. In our novel research, we used NiSe NPs ointment and NiSe‐incorporated PANI/PEO fibers for wound healing. The materials‐related characteristics were studied by UV/visible spectroscopy, FTIR, SEM, DLS, and XRD. SEM images illustrate the rod‐like structure of the NiSe, while bead‐free NiSe‐based PANI/PEO fibers are conformed from SEM with an average diameter of 330 nm. An average crystal size of 6.2 nm is measured from the XRD pattern. The antibacterial and antioxidant properties showed that NiSe‐incorporated PANI/PEO fibers exhibited better response than NiSe NPs with less toxicity. NiSe NPs and NiSe‐based PANI/PEO fibers give excellent wound healing potential of 89.5% ± 1.18% and 95.6% ± 0.25%, respectively. Healing response and tissue regeneration by NiSe‐incorporated PANI/PEO fibers were evaluated clinically by using histopathology and interleukin‐6, which indicated efficient and effective wound recovery.