Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer
This study demonstrates that hypofractionated RT and PT induced both similar and significantly distinct immune responses. PT triggers a stronger immunosuppressive response than RT. Optimizing the combination of PT with IT, including dose, fractionation, and sequencing is crucial for improving treatment efficacy.
Authors
- Corentin Richard (ORCID: https://orcid.org/0000-0001-9732-0219)
- Céline Mirjolet (ORCID: https://orcid.org/0000-0003-0047-9421)
- Emeric Limagne (ORCID: https://orcid.org/0000-0002-1098-8441)
- Jolie Bou-Gharios (ORCID: https://orcid.org/0000-0002-9984-913X)
- Anaïs Nicol
- Lisa Froidurot
- Pierre-Antoine Laurent (ORCID: https://orcid.org/0000-0002-1544-5390)
- Carole Mura (ORCID: https://orcid.org/0000-0003-0305-711X)
- Romain Boidot (ORCID: https://orcid.org/0000-0001-9956-1737)
- Hélène Burckel (ORCID: https://orcid.org/0000-0002-9612-5806)
- G. Noël (ORCID: https://orcid.org/0000-0003-4952-5572)
- Marc Rousseau
- Véronique Morgand
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pluridisciplinaire Hubert Curien (FR)
- Institut de Cancérologie Strasbourg (FR)
- Centre Georges François Leclerc (FR)
- NVH Medicinal (France) (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1186/s12967-025-06377-7
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Ligue Contre le Cancer
- Conseil régional de Bourgogne-Franche-Comté