Reduced high-density lipoprotein antioxidant function in patients with coronary artery disease and acute coronary syndrome
HDL function was measured in 2 cohorts: 1225 patients admitted electively for coronary angiography and 196 patients with ACS. A validated cell-free biochemical assay was used to determine reduced HDL antioxidant function, as assessed by increased HDL-lipid peroxide content (HDLox), which was normalized by HDL-C levels and the mean value of a pooled serum control from healthy participants (nHDLox; unitless). Results are expressed as median with interquartile range (IQR).
Authors
- Nazha Hamdani (ORCID: https://orcid.org/0000-0002-3053-0008)
- Philipp Hillmeister (ORCID: https://orcid.org/0000-0003-1749-2315)
- Timm Henning Westhoff (ORCID: https://orcid.org/0000-0001-5797-834X)
- Ivo Buschmann
- Nikolaos Pagonas (ORCID: https://orcid.org/0000-0003-3226-8135)
- Felix Sebastian Seibert (ORCID: https://orcid.org/0000-0003-4347-2481)
- Werner Dammermann (ORCID: https://orcid.org/0000-0001-6847-3769)
- Christian Ukena (ORCID: https://orcid.org/0000-0002-9810-4662)
- Martin Christ (ORCID: https://orcid.org/0000-0001-6435-5626)
- Benjamin Sasko (ORCID: https://orcid.org/0000-0001-8157-9875)
- Theodoros Kelesidis (ORCID: https://orcid.org/0000-0002-8463-3811)
- Linda Scharow
- Oliver Ritter (ORCID: https://orcid.org/0000-0003-2069-4364)
- Monique Jaensch
- R Mueller
Institutions
- Universitätsklinik Marien Hospital Herne (DE)
- Knappschaftskrankenhaus Recklinghausen (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- Czech Academy of Sciences, Institute of Physiology (CZ)
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
- The University of Texas Southwestern Medical Center (US)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- JCI Insight
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1172/jci.insight.187889
- Citations
- 6
- Primary Topic
- Paraoxonase enzyme and polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 7.91
Funders
- NIH Office of the Director