Immunosuppressive JAG2 <sup>+</sup> tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells
The emergence of JAG2<sup>+</sup> TANs is crucial for the differentiation of eTregs, which triggers immune evasion and resistance to anti-PD-1 therapy. Inhibiting Notch signaling with LY3039478 or JAG2 neutralization antibodies may overcome this anti-PD-1 resistance in HGSOC.
Authors
- Mengdi He (ORCID: https://orcid.org/0000-0003-2693-5261)
- Xueling Wang (ORCID: https://orcid.org/0000-0002-5969-5172)
- Chen Zhang (ORCID: https://orcid.org/0009-0005-1091-6316)
- Moran Yang (ORCID: https://orcid.org/0000-0002-0601-9090)
- Haiou Liu (ORCID: https://orcid.org/0000-0003-0200-8981)
- Kankan Cao (ORCID: https://orcid.org/0000-0001-9242-1440)
- Y C Zhong (ORCID: https://orcid.org/0009-0006-6559-0736)
- Yan Huang (ORCID: https://orcid.org/0000-0002-1789-5088)
- Chenyang Wang (ORCID: https://orcid.org/0009-0007-6895-4897)
- Guodong Zhang (ORCID: https://orcid.org/0000-0002-4310-6097)
- Jiaqi Lu (ORCID: https://orcid.org/0000-0002-5646-0298)
- Yiying Wang (ORCID: https://orcid.org/0000-0002-1252-7788)
Institutions
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1002/cac2.70021
- Citations
- 12
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 9.57
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China