Amino Acid Stress Response Genes Contribute to a 25‐Fold Increased Risk of L‐Asparaginase–Induced Hypersensitivity
The cumulative incidence of these large effect variants highlights their significance for the identification of patients at high risk of l-asparaginase-induced hypersensitivity. Successfully identifying patients at increased risk of hypersensitivity reactions can inform personalized treatment strategies and limit these harmful dose-limiting reactions in pediatric ALL.
Authors
- Edward J. Raack (ORCID: https://orcid.org/0000-0001-9730-9415)
- Erika N. Scott (ORCID: https://orcid.org/0000-0003-4660-7206)
- Miguel Córdova‐Delgado (ORCID: https://orcid.org/0000-0002-3132-226X)
- Bruce Carleton (ORCID: https://orcid.org/0000-0002-4485-4054)
- Colin J.D. Ross (ORCID: https://orcid.org/0000-0003-1476-7037)
- Jessica N. Trueman
- Shahrad R. Rassekh (ORCID: https://orcid.org/0000-0001-8005-2641)
- Catrina M. Loucks (ORCID: https://orcid.org/0000-0003-1167-3721)
- Spencer J. Anderson (ORCID: https://orcid.org/0000-0002-2969-8399)
- Wan‐Chun Chang (ORCID: https://orcid.org/0000-0001-7069-7083)
Institutions
- University of British Columbia (CA)
- BC Children's Hospital (CA)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1002/pbc.31668
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Genome Canada
- Genome British Columbia
- Provincial Health Services Authority
- Health Canada
- Canadian Institutes of Health Research