Differences in Observed Outcomes and Toxicities for Adolescent and Young Adult Patients With Aggressive Mature B‐Cell Lymphomas Treated at an Adult Versus Pediatric Cancer Center
Among patients with DLBCL, pediatric-inspired or more intensive therapies were associated with improved PFS compared with R-CHOP, hazard ratio of 0.33 (95% confidence interval: 0.11-0.98). Greater short-term toxicity and lower incidence of peripheral neuropathy were observed in AYA MBCL patients treated at a pediatric versus adult center.
Authors
- Mitchell Stuart Cairo (ORCID: https://orcid.org/0000-0002-2075-434X)
- Jonathan E. Brammer (ORCID: https://orcid.org/0000-0002-6229-3609)
- Allison LeHanka (ORCID: https://orcid.org/0009-0009-1545-3129)
- Anthony Audino (ORCID: https://orcid.org/0000-0002-2597-1212)
- Nicholas D. Yeager (ORCID: https://orcid.org/0000-0002-3733-5803)
- Robert A. Baiocchi (ORCID: https://orcid.org/0000-0002-1619-4853)
- Yazeed Sawalha (ORCID: https://orcid.org/0000-0001-6355-3671)
- Kami J. Maddocks (ORCID: https://orcid.org/0000-0001-8519-8404)
- Joseph Stanek (ORCID: https://orcid.org/0000-0003-1630-2102)
- Audrey M. Sigmund (ORCID: https://orcid.org/0000-0003-0706-4843)
- David A. Bond (ORCID: https://orcid.org/0000-0003-0773-1829)
- John Reneau (ORCID: https://orcid.org/0000-0001-6838-2410)
- Faye Willen
- Narendranath Epperla (ORCID: https://orcid.org/0000-0002-8216-3457)
- Timothy J. Voorhees (ORCID: https://orcid.org/0000-0001-7603-6454)
- Ann Kebede (ORCID: https://orcid.org/0009-0002-1917-4329)
- Neda Amirmokhtari
- Beth Christian
Institutions
- Nationwide Children's Hospital (US)
- New York Medical College (US)
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1002/pbc.31664
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00