Vitamin B6 deficiency produces metabolic alterations in Drosophila
Our results validate Drosophila as a suitable model to study in depth the molecular mechanisms underlying human diseases associated with vitamin B6 deficiency and confirmed that 4DP treatment is effective in inducing vitamin B6 deficiency.
Authors
- Michele De Rosa (ORCID: https://orcid.org/0000-0002-1242-3954)
- A. Patriarca (ORCID: https://orcid.org/0009-0005-4471-8107)
- Ottavia Giampaoli (ORCID: https://orcid.org/0000-0003-1336-3102)
- Fiammetta Vernı̀ (ORCID: https://orcid.org/0000-0001-8866-3324)
- Mariangela Spagnoli (ORCID: https://orcid.org/0000-0001-9061-7159)
- Fabio Sciubba (ORCID: https://orcid.org/0000-0002-1982-2712)
- Eleonora Pilesi (ORCID: https://orcid.org/0000-0001-6703-8001)
- Roberto Contestabile (ORCID: https://orcid.org/0000-0002-5235-9993)
- Angela Tramonti (ORCID: https://orcid.org/0000-0002-5625-1170)
- G Tesoriere (ORCID: https://orcid.org/0000-0002-6571-8801)
- Federica Chiocciolini
Institutions
- Institute of Molecular Biology and Pathology (IT)
- Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Metabolomics
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1007/s11306-025-02236-0
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Sapienza Università di Roma
- Consiglio Nazionale delle Ricerche
- Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro