Increased Na <sub>V</sub> 1.2 expression and its interaction with CaM contribute to the hyperexcitability induced by prolonged inhibition of CaMKII
We unveiled that prolonged CaMKII inhibition induced hyperexcitability through increasing the expression of Na<sub>V</sub>1.2 and its association with CaM. Thus, our study uncovers a novel signaling mechanism by which CaMKII maintains appropriate neuronal excitability.
Authors
- Qinghua Gao (ORCID: https://orcid.org/0000-0002-4362-2817)
- Wuyang Wang (ORCID: https://orcid.org/0000-0003-1875-5463)
- Feng Guo
- Tong Yu (ORCID: https://orcid.org/0000-0001-6644-4745)
- Zhiyi Yu (ORCID: https://orcid.org/0000-0001-6227-0610)
- Ke Du (ORCID: https://orcid.org/0000-0002-3975-0314)
- Rui Feng (ORCID: https://orcid.org/0000-0003-3895-8989)
- Dongxin Liu (ORCID: https://orcid.org/0000-0002-0956-5142)
- Jianjun Xu (ORCID: https://orcid.org/0000-0002-1855-8462)
- Tomasz Boczek (ORCID: https://orcid.org/0000-0002-7654-9011)
- Hongyue Liang (ORCID: https://orcid.org/0000-0001-9935-7779)
- Xuan Huang (ORCID: https://orcid.org/0000-0002-1116-0865)
- Corey R. Seehus (ORCID: https://orcid.org/0000-0002-8647-8579)
- Dongyi Zhao (ORCID: https://orcid.org/0000-0001-7209-6185)
- Ling Qin (ORCID: https://orcid.org/0000-0001-6173-6167)
- Yue Zhao
- Jaehoon Shim (ORCID: https://orcid.org/0000-0001-7981-2658)
- Meixuan Li (ORCID: https://orcid.org/0000-0001-9373-4086)
- Xinyu Cao (ORCID: https://orcid.org/0009-0000-9496-0974)
- Xiaoxue Xu (ORCID: https://orcid.org/0000-0003-1831-3657)
- Weidong Zhao
- Junwei Huang (ORCID: https://orcid.org/0009-0009-7144-0437)
- Li Wang (ORCID: https://orcid.org/0000-0003-2068-7535)
Institutions
- Kagoshima University (JP)
- Boston Children's Hospital (US)
- Shandong University (CN)
- Xuzhou Medical College (CN)
- Fourth Affiliated Hospital of China Medical University (CN)
- Medical University of Lodz (PL)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1111/epi.18377
- Citations
- 2
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province