Senescent vascular endothelial cells promote oral squamous cell carcinoma progression through complement C3 activation
Senescent VECs induced by cisplatin promote OSCC proliferation and invasion through complement C3 activation. Targeting complement C3 in senescent VECs may offer a novel therapeutic strategy for OSCC treatment.
Authors
- Fanglong Wu (ORCID: https://orcid.org/0000-0003-4506-1387)
- Junjiang Liu
- Fangqi Jing
- Jingtian Mu
- Can Hu (ORCID: https://orcid.org/0000-0002-8687-8310)
- Qinghong Gao
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Archives of Oral Biology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.archoralbio.2025.106242
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program
- Key Technologies Research and Development Program
- National Key Research and Development Program of China