BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway
These findings demonstrate that BDNF secreted by mesenchymal stem cells can improve the quality and development potential of oocytes from both aged mice and humans by activating the ERK1/2 signaling pathway, suggesting that it has the potential to mitigate age-related declines in oocyte quality.
Authors
- Shidou Zhao (ORCID: https://orcid.org/0000-0003-4722-1575)
- Keliang Wu (ORCID: https://orcid.org/0000-0001-9552-6096)
- Xin Mi
- Caiyi Chen (ORCID: https://orcid.org/0000-0003-1185-0812)
- Cheng Li (ORCID: https://orcid.org/0000-0002-5379-4815)
- Ran Liu (ORCID: https://orcid.org/0000-0002-9605-231X)
- Yingying Qin (ORCID: https://orcid.org/0000-0002-0319-7799)
- Jing Zhou (ORCID: https://orcid.org/0009-0009-3435-8629)
- Gang Liu (ORCID: https://orcid.org/0000-0002-0903-8713)
- Jiali Zhou (ORCID: https://orcid.org/0000-0003-2708-5588)
- Zi‐Jiang Chen (ORCID: https://orcid.org/0000-0001-6637-6631)
- Jiayi Ren
Institutions
- Shandong University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Renji Hospital (CN)
- Second Hospital of Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1186/s12964-025-02137-8
- Citations
- 5
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 9.39
Funders
- Taishan Scholar Foundation of Shandong Province
- National Natural Science Foundation of China
- Key Technology Research and Development Program of Shandong
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- Natural Science Fund for Distinguished Young Scholars of Shandong Province
- National Key Research and Development Program of China
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine