Prevalence and Clinical Characteristics of the <scp> <i>LRRK2</i> </scp> p. <scp>L1795F</scp> Variant in Central Europeans with Early‐Onset and Familial Parkinson's Disease
Our data indicate that p.L1795F contributes to PD in Central Europe. Further exploration in larger cohorts is warranted to establish its contribution to global PD risk.
Authors
- Patrick A. Lewis (ORCID: https://orcid.org/0000-0003-4537-0489)
- Petr Hollý (ORCID: https://orcid.org/0000-0002-5242-8725)
- Kateřina Zárubová
- Gertrúd Tamás (ORCID: https://orcid.org/0000-0001-8054-3678)
- Katarzyna Śmiłowska (ORCID: https://orcid.org/0000-0001-9167-1624)
- Zuzana Gdovinová (ORCID: https://orcid.org/0000-0002-7396-5052)
- Vladimír Haň (ORCID: https://orcid.org/0000-0003-1942-3778)
- Kristína Kulcsárová (ORCID: https://orcid.org/0000-0003-3135-1826)
- Veronika Magocova
- Egon Kurča (ORCID: https://orcid.org/0000-0002-1025-6830)
- David Murphy (ORCID: https://orcid.org/0000-0002-3771-3800)
- Igor Straka (ORCID: https://orcid.org/0000-0003-1134-7029)
- Petr Dušek (ORCID: https://orcid.org/0000-0003-4877-9642)
- Robert Jech (ORCID: https://orcid.org/0000-0002-9732-8947)
- Mária Mareková (ORCID: https://orcid.org/0000-0002-9103-4710)
- Dávid Pintér (ORCID: https://orcid.org/0000-0002-0734-6878)
- A. Nagano (ORCID: https://orcid.org/0000-0002-2354-660X)
- Tatiana Svoreňová
- Péter Klivènyi (ORCID: https://orcid.org/0000-0002-5389-3266)
- Miriam Ostrožovičová (ORCID: https://orcid.org/0000-0003-1519-1535)
- Miroslava Rabajdová (ORCID: https://orcid.org/0000-0001-9562-5756)
- Milan Grofik (ORCID: https://orcid.org/0000-0003-0464-0497)
- Evžen Růžička (ORCID: https://orcid.org/0000-0002-4893-9661)
- Norbert Kovács (ORCID: https://orcid.org/0000-0002-7332-9240)
- Katarína Kalinová (ORCID: https://orcid.org/0000-0002-4773-0823)
- Ján Necpál (ORCID: https://orcid.org/0000-0002-4626-9588)
- Mie Rizig (ORCID: https://orcid.org/0000-0003-2420-4449)
- Henry Houlden (ORCID: https://orcid.org/0000-0002-2866-7777)
- Alexandra Lacková (ORCID: https://orcid.org/0000-0002-8286-0607)
- Matěj Škorvánek (ORCID: https://orcid.org/0000-0001-5497-8715)
- Tereza Serranová (ORCID: https://orcid.org/0000-0001-6525-3971)
- Hamin Lee (ORCID: https://orcid.org/0009-0002-0839-8263)
- Krisztina Soos
- Peter Valkovic
- Agsha Atputhavadivel
Institutions
- Semmelweis University (HU)
- Royal Veterinary College (GB)
- Medical University of Graz (AT)
- University of Pavol Jozef Šafárik (SK)
- Slovak Academy of Sciences (SK)
- Charles University (CZ)
- University of Szeged (HU)
- University Hospital Bratislava (SK)
- University Hospital in Motol (CZ)
- Technická univerzita vo Zvolene (SK)
- Univerzitná Nemocnica Louisa Pasteura (SK)
- Centre of Experimental Medicine of the Slovak Academy of Sciences (SK)
- National Hospital for Neurology and Neurosurgery (GB)
- Institute of Normal and Pathological Physiology of the Slovak Academy of Sciences (SK)
- General University Hospital in Prague (CZ)
- University College London (GB)
- Comenius University Bratislava (SK)
- University of Pecs (HU)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1002/mdc3.70045
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Institute for Health and Care Research
- University College London