Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis
SYD combats CRC via dual modulation of IL-17/TNF/NF-κB signaling and GM ecosystems (e.g., Akkermansia enrichment). This microbiota-immune crosstalk positions SYD as a potential adjunct to conventional therapies, particularly for CRC patients with dysbiosis.
Authors
- Wenhao Ye (ORCID: https://orcid.org/0009-0009-2600-4484)
- Xiao‐Jiang Hao (ORCID: https://orcid.org/0000-0001-9496-2152)
- Yuexing Chao
- Xiaolin Li (ORCID: https://orcid.org/0000-0003-1524-051X)
- Guiyu Zhang (ORCID: https://orcid.org/0000-0002-5948-9504)
- Yuan Rong (ORCID: https://orcid.org/0000-0003-0675-8421)
- Shaodong Gu
- LeAnn Kuhlmann Qi
- Wuhong Zhang
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cam4.70813
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42