Posttransplant EBV‐Positive Smooth Muscle Tumors in Children, Adolescents, and Young Adults: A Multi‐Institution Experience
Epstein-Barr virus (EBV)-positive smooth muscle tumors (SMTs) are rare tumors seen in immunocompromised patients. There is no clear standard of care for the management and treatment of EBV-SMTs. Patients are often treated with chemotherapy, surgery, and/or radiation. Additional options include antiretroviral treatment, reduction in immunosuppression, and EBV-directed virus-specific T cells (VSTs). This report describes the treatment regimens and outcomes of eight patients with EBV-associated SMTs. Although no consensus treatment for EBV-SMTs has been identified, VSTs show promise in providing a period of stable disease or partial response and surgical removal may offer long-term benefits in cases of localized disease.
Authors
- Anthony Audino (ORCID: https://orcid.org/0000-0002-2597-1212)
- James B. Ford (ORCID: https://orcid.org/0000-0001-9716-3049)
- Lynda Villagomez
- Kaitlin J. Devine (ORCID: https://orcid.org/0000-0002-6130-4724)
- Jeremy D. Rubinstein (ORCID: https://orcid.org/0000-0002-1934-2954)
- Meghan G. Haney (ORCID: https://orcid.org/0000-0002-6088-8553)
- Ann Kebede (ORCID: https://orcid.org/0009-0002-1917-4329)
- Ana C. Xavier (ORCID: https://orcid.org/0000-0002-3659-3798)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Nationwide Children's Hospital (US)
- Primary Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- University of Utah (US)
- University of Alabama at Birmingham (US)
- The Ohio State University (US)
- University of Pennsylvania (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1002/pbc.31678
- Citations
- 2
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.09