Soluble Thrombomodulin Is Associated With Endothelial Dysfunction Syndromes After Pediatric Hematopoietic Stem Cell Transplantation
High sTM levels early after pediatric HSCT are associated with the development of SOS, CLS, and severe aGvHD. These results suggest that conditioning-induced endothelial damage and activation of pro-thrombotic environment play key roles in the pathogenesis of these syndromes, indicating that sTM may prove clinically useful to guide early diagnosis and treatment of endothelial damage syndromes.
Authors
- Pär I. Johansson (ORCID: https://orcid.org/0000-0001-9778-5964)
- Katrine Kielsen (ORCID: https://orcid.org/0000-0002-7167-012X)
- Klaus Müller (ORCID: https://orcid.org/0000-0002-5278-1983)
- Claus Henrik Nielsen (ORCID: https://orcid.org/0000-0001-7543-9016)
- Marianne Ifversen (ORCID: https://orcid.org/0000-0002-2558-1935)
- Denise Elbæk Horan (ORCID: https://orcid.org/0000-0002-7501-770X)
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1002/pbc.31675
- Citations
- 1
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Dagmar Marshalls Fond
- Kræftens Bekæmpelse