73P Cognitive toxicity of avapritinib: A case series

Avapritinib is a KIT and PDGFRA inhibitor with high potency against KIT D816V and PDGFRA D842V mutations, and is used primarily in advanced GIST with PDGFRA D842V mutation. In the landmark phase III VOYAGER trial, cognitive events of any grade were reported in 26% of patients treated with avapritinib (grade 3: 1.3%). It is hypothesised that inhibition of PDGFRβ may lead to disruption of the blood-brain barrier and accumulation of neurotoxic proteins.

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Publication Details

Journal
ESMO Open
Published
2025-03-01
DOI
https://doi.org/10.1016/j.esmoop.2025.104387
Primary Topic
Multiple Myeloma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

73P Cognitive toxicity of avapritinib: A case series

Andressa Bernardi, Émilie Turcotte
ESMO Open
Multiple Myeloma Research and Treatments
article

73P Cognitive toxicity of avapritinib: A case series

Andressa Bernardi, Émilie Turcotte
article en

Abstract

Avapritinib is a KIT and PDGFRA inhibitor with high potency against KIT D816V and PDGFRA D842V mutations, and is used primarily in advanced GIST with PDGFRA D842V mutation. In the landmark phase III VOYAGER trial, cognitive events of any grade were reported in 26% of patients treated with avapritinib (grade 3: 1.3%). It is hypothesised that inhibition of PDGFRβ may lead to disruption of the blood-brain barrier and accumulation of neurotoxic proteins.

ESMO OpenVol. 10
Zero hunger
Openalex Percentile: Top 93%
Multiple Myeloma Research and Treatments
DOIOpen Access PDFOpenAlex
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73P Cognitive toxicity of avapritinib: A case series — Andressa Bernardi, Émilie Turcotte · ESMO Open (2025) | TGRS Research Map | TGRS