Associations between physical fitness and structural and functional MRI measures in secondary progressive multiple sclerosis: Cross-sectional findings from the exercise PRO-MS study
In our cohort of 29 people with SPMS, no statistically significant associations were found between physical fitness and brain volumetric measures. A potential tendency towards associations were observed between better cardiorespiratory fitness and higher rsFC of the SMN-brain and higher self-reported level of physical activity and higher rsFC of the DMN-brain, suggesting a potential effect of physical fitness on functional brain connectivity in SPMS.
Authors
- Chris Vriend (ORCID: https://orcid.org/0000-0003-3111-1304)
- Arianne Sophia Gravesteijn (ORCID: https://orcid.org/0000-0002-2458-2346)
- Erwin E. H. van Wegen (ORCID: https://orcid.org/0000-0002-7920-9995)
- Hanneke E. Hulst (ORCID: https://orcid.org/0000-0002-5039-1359)
- Brigit A. de Jong (ORCID: https://orcid.org/0000-0002-7005-7008)
- Vincent de Groot (ORCID: https://orcid.org/0000-0002-6073-6250)
- Odile A. van den Heuvel (ORCID: https://orcid.org/0000-0002-9804-7653)
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Heleen Beckerman (ORCID: https://orcid.org/0000-0002-8421-3630)
- Amber van der Kruit
- M Bet
Institutions
- Leiden University (NL)
- University of Applied Sciences Leiden (NL)
- Leiden University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.msard.2025.106407
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47