SWI/SNF complexes govern ontology-specific transcription factor function in MYC-subtype atypical teratoid rhabdoid tumor
These results demonstrate SWI/SNF complexes are critical for lineage-specific TF binding and activity at both promoters and enhancers. In the context of ATRT, these findings reveal a previously underappreciated therapeutic vulnerability in targeting residual promoter-proximal TF function in ATRT.
Authors
- Jizhi Ge
- David J. Daniels (ORCID: https://orcid.org/0000-0002-0702-1459)
- Yuqian Yan (ORCID: https://orcid.org/0000-0002-1646-7276)
- Cody L. Nesvick (ORCID: https://orcid.org/0000-0002-2249-5054)
- Feda H. Hamdan (ORCID: https://orcid.org/0000-0003-2455-2435)
- Alexandre Gaspar‐Maia (ORCID: https://orcid.org/0000-0001-8528-5575)
- Steven A. Johnsen
- Jacob B. Anderson (ORCID: https://orcid.org/0000-0003-1343-3908)
- Alexander Q. Wixom
- Liang Zhang (ORCID: https://orcid.org/0000-0001-9218-828X)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Robert Bosch Hospital (DE)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Neurological Surgery (US)
- Epigenomics (Germany) (DE)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1093/neuonc/noaf081
- Citations
- 2
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61