Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings
Ultra represents a valuable tool for rapid RR-TB detection; however, in low prevalence settings its low positive predictive value for RR detection is largely driven by samples with very low bacillary loads. As programs expand active case-finding and early detection of asymptomatic disease, the proportion of TB detected with very low bacillary load will increase. Diagnostic algorithms require adjustments to prevent unnecessary RR-TB treatment.
Authors
- Ellen M.H. Mitchell (ORCID: https://orcid.org/0000-0002-2824-3499)
- Tom Decroo (ORCID: https://orcid.org/0000-0002-1205-1484)
- François Hakizayezu
- Leen Rigouts (ORCID: https://orcid.org/0000-0003-3301-9480)
- Jelle Keysers
- Claude Mambo Muvunyi (ORCID: https://orcid.org/0000-0003-4180-442X)
- Bouke C. de Jong (ORCID: https://orcid.org/0000-0002-1017-4675)
- Willem Bram de Rijk
- Isabel Cuella Martin (ORCID: https://orcid.org/0000-0001-7543-3386)
- Ayman Ahmed (ORCID: https://orcid.org/0000-0002-9516-9508)
- Patrick Migambi (ORCID: https://orcid.org/0000-0003-4344-2872)
- Hosee Niyompano
- Yves Mucyo Habimana (ORCID: https://orcid.org/0000-0001-6097-1405)
- Wim Mulders (ORCID: https://orcid.org/0000-0002-9566-3653)
- Jean Claude Semuto Ngabonziza (ORCID: https://orcid.org/0000-0002-6075-5603)
- Docteur Runyambo
Institutions
- University of Antwerp (BE)
- University of Khartoum (SD)
- University of Kigali (RW)
- University of Rwanda (RW)
- Public Health Institute (US)
- Centre Hospitalier Universitaire de Kigali (RW)
- Rwanda Biomedical Center (RW)
- Instituut voor Tropische Geneeskunde (BE)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1093/cid/ciaf132
- Citations
- 3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.19