Predicting OCT retinal ganglion cell volume from pattern ERGs and VEPs in children with suspected optic neuropathy in a tertiary referral setting
Abnormal PERG N95 slopes and PVEPs predicted severe loss of macular RGC volume and temporal sector RNFL with high diagnostic accuracy. These measures are important additions to the less specific PERG N95:P50, which was broadly sensitive to all RNFL sectors. The N95 slope and PVEPs are valuable objective functional markers of RGC health in children.
Authors
- Benjamin Evans (ORCID: https://orcid.org/0000-0001-6611-4500)
- Katrina L. Prise
- Oliver R. Marmoy (ORCID: https://orcid.org/0000-0003-2022-3669)
- Richard Bowman (ORCID: https://orcid.org/0000-0001-5422-4104)
- Siân E. Handley (ORCID: https://orcid.org/0000-0002-7612-3889)
- Lisa Tucker (ORCID: https://orcid.org/0000-0002-8123-3951)
- Dorothy Thompson (ORCID: https://orcid.org/0000-0001-5491-3911)
- Dermot Roche
Institutions
- City, University of London (GB)
- Great Ormond Street Hospital (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- BMJ Open Ophthalmology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/bmjophth-2024-001899
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- NIHR Great Ormond Street Hospital Biomedical Research Centre