Physical training reduces cell senescence and associated insulin resistance in skeletal muscle
These findings highlight the role of CS in regulating insulin sensitivity in SkM and underscore the therapeutic potential of exercise in mitigating age- and obesity-related muscle dysfunction. Targeting CS through exercise or senolytic agents could offer a promising strategy for improving metabolic health and combating sarcopenia, particularly in at-risk populations.
Authors
- Annika Nerstedt (ORCID: https://orcid.org/0000-0002-2607-6236)
- Ulf Smith (ORCID: https://orcid.org/0000-0002-1439-4608)
- Rosa Spinelli (ORCID: https://orcid.org/0000-0001-7308-4119)
- Federica Zatterale (ORCID: https://orcid.org/0000-0002-1653-8652)
- Matthias Blüher (ORCID: https://orcid.org/0000-0003-0208-2065)
- Agnieszka Podraza-Farhanieh (ORCID: https://orcid.org/0000-0002-1120-8216)
- Silvia Gogg (ORCID: https://orcid.org/0000-0001-7104-7269)
Institutions
- Helmholtz Centre for Environmental Research (DE)
- University Hospital Leipzig (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.molmet.2025.102130
- Citations
- 5
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Knut och Alice Wallenbergs Stiftelse
- Svenska Diabetesstiftelsen
- Novo Nordisk Fonden