High-salt diet drives depression-like behavior in mice by inducing IL-17A production

Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD causes depression remains unclear. In this study, HSD induces depression-like behavior in mice accompanied by an increase in IL-17A production. RORγt deficiency abolishes HSD-induced depression-like behavior in mice. Furthermore, γδT17 cells are identified as an important cellular source of IL-17A in mice with HSD-induced depression. Depletion of γδT cells using anti-TCRγδ antibody markedly alleviates depression-like behavior in mice with HSD. Our findings demonstrate that increased dietary salt intake facilitates the development of depression at least partially through the induction of γδT17 cells.

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Publication Details

Journal
The Journal of Immunology
Published
2025-03-22
DOI
https://doi.org/10.1093/jimmun/vkaf019
Citations
2
Primary Topic
Sodium Intake and Health
Type
article
Field-Weighted Citation Impact
2.24

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article

High-salt diet drives depression-like behavior in mice by inducing IL-17A production

Yue Wu, Xiaojun Chen, Haiyan Yan, Ying Chen et al.
2 citations
The Journal of Immunology
Sodium Intake and Health
2.24
article

High-salt diet drives depression-like behavior in mice by inducing IL-17A production

Yue Wu, Xiaojun Chen, Haiyan Yan, Ying Chen, Lei Xu, W.T. Chen, Wenhui Sun, Zhigang Lei, Chuan Wei, S. Zhou, Chuan Su, Wei Li, Na Li, Yalin Li, Xuan Xie, Jifeng Zhu, Di Lu
article en
2 citations

Abstract

Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD causes depression remains unclear. In this study, HSD induces depression-like behavior in mice accompanied by an increase in IL-17A production. RORγt deficiency abolishes HSD-induced depression-like behavior in mice. Furthermore, γδT17 cells are identified as an important cellular source of IL-17A in mice with HSD-induced depression. Depletion of γδT cells using anti-TCRγδ antibody markedly alleviates depression-like behavior in mice with HSD. Our findings demonstrate that increased dietary salt intake facilitates the development of depression at least partially through the induction of γδT17 cells.

The Journal of ImmunologyVol. 214(4)
Shaoxing University (CN), Wuxi People's Hospital (CN), Nanjing Medical University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province
Good health and well-being
Openalex Percentile: Top 15%
Sodium Intake and Health
2.24
DOIOpen Access PDFOpenAlex
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