Bioinformatics Identification of Lactate‐Associated Genes in Hepatocellular Carcinoma: <scp>G6PD</scp>'s Role in Immune Modulation
This study establishes lactate metabolism genes, particularly G6PD, as key prognostic markers in HCC. The validation of G6PD's immunomodulatory effects further supports its potential as a therapeutic target for strategies aimed at enhancing immune surveillance and treatment outcomes in HCC.
Authors
- Qin Pan (ORCID: https://orcid.org/0000-0002-4210-2852)
- Haoran Qu
- Hongyan Wu (ORCID: https://orcid.org/0000-0002-6887-2548)
- Xiao‐Lian Zhang (ORCID: https://orcid.org/0000-0002-8283-9381)
- Yao‐yi‐ao Shu (ORCID: https://orcid.org/0000-0003-1785-0784)
- Wenwen Zhang (ORCID: https://orcid.org/0000-0003-1285-3118)
- Fengling Luo
- Chaoqun Wang (ORCID: https://orcid.org/0000-0001-9912-9477)
- Min Liu (ORCID: https://orcid.org/0000-0001-7095-1344)
- Xueming Du (ORCID: https://orcid.org/0000-0002-7146-6735)
- Chenghao Liu (ORCID: https://orcid.org/0000-0001-7976-1264)
- Xicheng Wang (ORCID: https://orcid.org/0000-0001-6677-850X)
- Sujuan Sun
Institutions
- China Three Gorges University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cam4.70801
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China