Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the <scp>HLA</scp> Class <scp>II</scp> Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthr
Although citrulline-glycine motifs are prevalent ACPA targets, our data reveal that HLA SE alleles are primarily associated with ACPA to nonglycine citrulline motifs, providing insight in ACPA T cell dependance. Yet, the etiologic significance of ACPA targeting different protein structures remains unknown.
Authors
- Espen Andre Haavardsholm (ORCID: https://orcid.org/0000-0002-1427-4745)
- Isabel Gehring (ORCID: https://orcid.org/0000-0002-2516-5261)
- Jessica Rojas‐Restrepo
- Leonid Padyukov (ORCID: https://orcid.org/0000-0003-2950-5670)
- Saedís Saevarsdóttir (ORCID: https://orcid.org/0000-0001-9392-6184)
- Hilde Berner Hammer (ORCID: https://orcid.org/0000-0001-7317-8991)
- Johan Askling (ORCID: https://orcid.org/0000-0003-0433-0616)
- Tore Kristian Kvien (ORCID: https://orcid.org/0000-0002-8441-3093)
- Nasim Ghasemzadeh
- Siri Lillegraven (ORCID: https://orcid.org/0000-0003-3615-0134)
- Merete Lund Hetland (ORCID: https://orcid.org/0000-0003-4229-6818)
- Caroline Grönwall (ORCID: https://orcid.org/0000-0002-9111-5537)
- Linda Mathsson Alm
- Bente Glintborg (ORCID: https://orcid.org/0000-0002-8931-8482)
- Helga Westerlind (ORCID: https://orcid.org/0000-0003-3380-5342)
- Joe Sexton (ORCID: https://orcid.org/0000-0003-4717-9637)
- Monika Hansson
Institutions
- Uppsala University (SE)
- University of Copenhagen (DK)
- deCODE Genetics (Iceland) (IS)
- Karolinska University Hospital (SE)
- University of Iceland (IS)
- University of Oslo (NO)
- Glostrup Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Thermo Fisher Scientific (Sweden) (SE)
- National University Hospital of Iceland (IS)
- Diakonhjemmet Hospital (NO)
- Thermo Fisher Scientific (Germany) (DE)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1002/art.43161
- Citations
- 4
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Innovationsfonden
- Bundesministerium für Bildung und Forschung
- Vetenskapsrådet
- NordForsk
- Norges Forskningsråd
- Stiftelsen Konung Gustaf V:s 80-årsfond
- Reumatikerförbundet