Preclinical B cell depletion and safety profile of a brain‐shuttled crystallizable fragment‐silenced CD20 antibody
The BBB hinders mAb-based brain disorder therapies A brain-targeted B-cell-depleting mAb for MS that efficiently crosses the BBB via hTfR1 was developed using Brainshuttle<sup>™</sup> technology (1a and 1b) The Brainshuttle<sup>™</sup>-CD20 mAb was well tolerated (2a and 2b) and displayed B-cell-killing properties (1c), paving the way for future development and clinical translation of TfR1-targetingtherapies for increased brain penetration.
Authors
- Sylvia Herter (ORCID: https://orcid.org/0000-0002-2446-696X)
- H.‐Christian von Büdingen (ORCID: https://orcid.org/0000-0003-0159-6662)
- Elisa Di Lenarda
- Shanon Seger (ORCID: https://orcid.org/0000-0001-6600-2349)
- Vanessa Schumacher (ORCID: https://orcid.org/0000-0003-4882-9881)
- Claudia Senn
- Eduard Urich (ORCID: https://orcid.org/0000-0003-0238-5517)
- Martina Stirn
- Cordula Jany
- Alain C. Tissot
- Johannes Auer (ORCID: https://orcid.org/0000-0002-8780-9704)
- Solen Pichereau
- Anne Eichinger‐Chapelon (ORCID: https://orcid.org/0000-0002-7228-5928)
- Adrian Roth (ORCID: https://orcid.org/0000-0003-3164-3300)
- Kevin Brady (ORCID: https://orcid.org/0000-0002-3256-5968)
- Michael B. Otteneder
- Juliana Bessa (ORCID: https://orcid.org/0000-0001-6730-3792)
- Anja Kipar (ORCID: https://orcid.org/0000-0001-7289-3459)
- Christian Klein (ORCID: https://orcid.org/0000-0001-7594-7280)
- Nadine Stokar‐Regenscheit (ORCID: https://orcid.org/0000-0003-4089-2026)
- Juergen Bachl
- Michael Winter (ORCID: https://orcid.org/0000-0003-4667-576X)
- Nicole Clemann
- Felix Weber (ORCID: https://orcid.org/0000-0003-3367-5795)
- Robert M. Mader (ORCID: https://orcid.org/0000-0003-3017-8240)
- Mohammed Ullah (ORCID: https://orcid.org/0000-0003-3263-983X)
- Niels Janssen
- J. F. Hönig
Institutions
- Roche (Switzerland) (CH)
- University of Liverpool (GB)
- University of Zurich (CH)
- Roche Pharma AG (Germany) (DE)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70178
- Citations
- 1
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 1.36