HIF‐1α‐induced long noncoding RNA LINC02776 promotes drug resistance of ovarian cancer by increasing polyADP‐ribosylation
LINC02776 promotes OC cell proliferation by regulating DNA damage and apoptosis signaling pathways. LINC02776 binds PARP1 to promote DNA damage-triggered PARylation in OC cells. LINC02776 mediates cisplatin and olaparib resistance in OC cells by enhancing PARP1-mediated PARylation activity and regulating the PARP1-mediated HR pathway. The high expression of LINC02776 is induced by HIF-1α in platinum-resistant OC cells and tissues.
Authors
- Chaohua Liu
- Xinyu Ha (ORCID: https://orcid.org/0009-0002-9598-3451)
- Yong Wu (ORCID: https://orcid.org/0000-0003-3764-3846)
- Xingzhu Ju (ORCID: https://orcid.org/0000-0002-4508-2025)
- Lulu Yang (ORCID: https://orcid.org/0000-0002-3979-2522)
- Linhui Liang (ORCID: https://orcid.org/0000-0002-1284-138X)
- Bin Zheng
- Shengli Li (ORCID: https://orcid.org/0000-0001-5430-303X)
- Ziqi Liu (ORCID: https://orcid.org/0000-0002-0220-1637)
- Zheng Feng
- Hao Wen (ORCID: https://orcid.org/0000-0002-9587-8742)
- Xiaohua Wu (ORCID: https://orcid.org/0000-0002-2271-2514)
- Jiajia Wang (ORCID: https://orcid.org/0000-0001-9652-1123)
- Yu Zeng (ORCID: https://orcid.org/0000-0003-4432-6443)
- Shenglin Huang
- Jun Wang (ORCID: https://orcid.org/0000-0002-6591-3316)
- Yangjun Wu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70244
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Chinese Society of Clinical Oncology
- Shanghai Rising-Star Program