A Phase III Randomized, Double-Blind, Active-Controlled, Multicenter Study on the Efficacy and Safety of Ezetimibe/Atorvastatin/Amlodipine Combination in Patients With Comorbid Primary Hypercholesterolemia and Essential Hypertension
Triple combination therapy with Eze/Ato + Aml has effectively reduced the LDL-C and SBP independently, compared with either Eze/Ato or Aml therapies over 8 weeks of treatment period. In terms of safety, there were no significant differences among the 3 treatment groups. This research lays the groundwork for the development of a triple fixed-dose combination in the future, which could improve patient convenience and adherence by reducing pill burden. Clinical Research Information Service (CRIS), Republic of Korea: KCT0006283.
Authors
- Jung Hyun Choi (ORCID: https://orcid.org/0000-0001-7171-8843)
- Kye Hun Kim (ORCID: https://orcid.org/0000-0002-6885-1501)
- Jin‐Oh Choi (ORCID: https://orcid.org/0000-0002-2441-2267)
- Eung Ju Kim (ORCID: https://orcid.org/0000-0003-2322-6267)
- Seung Hwan Han (ORCID: https://orcid.org/0000-0002-7975-6067)
- Byung‐Hee Hwang (ORCID: https://orcid.org/0000-0001-7770-0791)
- Jinho Shin (ORCID: https://orcid.org/0000-0001-6706-6504)
- Ji Yong Choi (ORCID: https://orcid.org/0000-0003-3155-3196)
- Young Won Yoon (ORCID: https://orcid.org/0000-0002-0907-0350)
- Seok‐Min Kang (ORCID: https://orcid.org/0000-0001-9856-9227)
- Pil Hyung Lee (ORCID: https://orcid.org/0000-0001-7339-9188)
- Jung‐Hoon Sung (ORCID: https://orcid.org/0000-0003-3515-5283)
- Chan Joo Lee (ORCID: https://orcid.org/0000-0002-8756-409X)
Institutions
- Ulsan College (KR)
- Yonsei University (KR)
- Severance Hospital (KR)
- Korea University Medical Center (KR)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- University of Ulsan (KR)
- Daegu Catholic University Medical Center (KR)
- Chonnam National University Hospital (KR)
- CHA University Bundang Medical Center (KR)
- Hanyang University Seoul Hospital (KR)
- Gangnam Severance Hospital (KR)
- CHA University (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Yonsei University Health System (KR)
- Deleted Institution
- Pusan National University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Clinical Therapeutics
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.clinthera.2025.03.001
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Yuhan