Endothelial cells microRNAs participation in the angiogenesis regulation

The 20th century marked the understanding that more than 80% of genes have an additional biological function in the cell associated with the regulation of the expression of other genes. Non-coding sequential-type RNA regulators, including microRNAs, capable of changing the expression of proteins in the cell, can be expressed with such genes. MicroRNAs are singlestranded RNA sequences 20–25 nucleotides in length that regulate gene expression at the posttranscriptional level through degradation or repression of mRNA translation. This review examines aspects of the biogenesis of microRNAs in mammalian cells, as well as their functions in endothelial cells and in the regulation of angiogenesis.