Increased functional connectivity of motor regions and dorsolateral prefrontal cortex in musicians with focal hand dystonia

The findings are consistent with previous research, highlighting the pathophysiological importance of the basal ganglia. Altered resting-state functional connectivity may reflect underlying neuroplastic changes in musicians with dystonia that lead to an altered flow of information, disrupting movement inhibition. Involvement of the dorsolateral prefrontal and premotor cortices further suggests that motor disturbances occur in the early planning phase of a movement. The findings indicate that a holistic re-training approach with and without the instrument could be beneficial for regaining motor control.