Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface
The study suggests that the ER stress response, which is triggered by cGVHD in ocular surface tissues, can be suppressed by PBA, an ER stress suppressor, potentially offering therapeutic benefits in ocular GVHD.
Authors
- Kazuo Tsubota (ORCID: https://orcid.org/0000-0002-8874-7111)
- Eisuke Shimizu (ORCID: https://orcid.org/0000-0002-3422-8578)
- Kazuno Negishi (ORCID: https://orcid.org/0000-0002-2892-9810)
- Shinri Sato (ORCID: https://orcid.org/0000-0002-8500-4507)
- Kazuki Asai (ORCID: https://orcid.org/0000-0002-9417-5690)
- Masatoshi Hirayama (ORCID: https://orcid.org/0000-0003-3653-6344)
- Yoko Ogawa (ORCID: https://orcid.org/0000-0002-2906-9621)
Institutions
- Keio University (JP)
- American Occupational Therapy Association (US)
- Keio University Hospital (JP)
Publication Details
- Journal
- The Ocular Surface
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.jtos.2025.03.003
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00