Vascular injury and occurrence of microthrombi after endovascular therapy for acute ischaemic stroke in a thromboembolic model
In this preclinical thromboembolic model, SR thrombectomy and DA lead to acute vascular injury, yield microthrombi and trigger contact activation of the coagulation system. At 3 days after intervention, healing remains incomplete, showing remnant vascular injury in the treated arteries, especially in SR thrombectomy.
Authors
- Joaquim Bobí (ORCID: https://orcid.org/0000-0002-9026-5226)
- Hajo Hund (ORCID: https://orcid.org/0000-0002-8625-6220)
- Hugo Ten Cate (ORCID: https://orcid.org/0000-0001-7796-4463)
- Heleen M.M. van Beusekom (ORCID: https://orcid.org/0000-0002-2930-1152)
- Diederik W.J. Dippel (ORCID: https://orcid.org/0000-0002-9234-3515)
- Aladdin Taha (ORCID: https://orcid.org/0000-0002-1300-7477)
- Khay van Noorden
- Magdolna Nagy (ORCID: https://orcid.org/0000-0001-8575-5936)
- Henri M.H. Spronk (ORCID: https://orcid.org/0000-0002-3858-334X)
- Dirk Jan Duncker (ORCID: https://orcid.org/0000-0003-2836-2241)
- Angelique Ceulemans (ORCID: https://orcid.org/0000-0002-2172-1646)
- Adriaan C.G.M. van Es (ORCID: https://orcid.org/0000-0001-6119-7247)
- Robert J van Oostenbrugge
- Pieter Jan van Doormaal
Institutions
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Medisch Centrum Haaglanden (NL)
Publication Details
- Journal
- BMJ Neurology Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/bmjno-2024-000989
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71