Osteoarthritis increases the risk of inflammatory arthritis due to immune checkpoint inhibitors associated with tissue-resident memory T cells
This study, the first of its kind, identifies OA as a significant risk factor for irAEarthritis. It reveals a potential mechanism by which ICIs activate PD-1-positive T<sub>RM</sub> cells in OA joints, resulting in tissue inflammation and irAE-arthritis. This research could significantly enhance the management and treatment of patients with cancer receiving ICIs.
Authors
- Yevgeniya Gartshteyn (ORCID: https://orcid.org/0000-0001-5547-4658)
- Adam Mor (ORCID: https://orcid.org/0000-0002-1065-2999)
- Matthieu Paiola (ORCID: https://orcid.org/0000-0002-3536-861X)
- Daniel M Portnoy
- Shoiab Bukhari (ORCID: https://orcid.org/0000-0002-1172-7139)
- ROBERT J. WINCHESTER (ORCID: https://orcid.org/0000-0002-7543-8037)
- Brian S. Henick (ORCID: https://orcid.org/0000-0003-2681-0805)
- Luke Hao (ORCID: https://orcid.org/0000-0003-4251-3595)
Institutions
- Columbia University Irving Medical Center (US)
- Columbia University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-010758
- Citations
- 12
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 12.54
Funders
- Roche
- National Institutes of Health