Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer
We elucidated the molecular mechanisms underlying the simultaneous occurrence of ferroptosis resistance and immune suppression in PDAC patients. Our study provides a novel therapeutic strategy that could promote ferroptosis in tumour cells and increase immunotherapy efficacy.
Authors
- Qiaowei Li (ORCID: https://orcid.org/0000-0002-5987-9465)
- Cheng‐Yu Liao (ORCID: https://orcid.org/0000-0001-7221-7522)
- Zuwei Wang
- Yi-Feng Tian
- Ge Li (ORCID: https://orcid.org/0009-0004-2709-8148)
- Yinghao Chen (ORCID: https://orcid.org/0000-0002-9176-8394)
- Hongyi Lin
- Zhiyuan Li (ORCID: https://orcid.org/0000-0001-5963-4225)
- Shi Chen (ORCID: https://orcid.org/0000-0002-8207-7479)
- Shun‐Cang Zhu (ORCID: https://orcid.org/0000-0002-6975-3583)
- Xiaoyan Lin
- Chengke Xie (ORCID: https://orcid.org/0000-0002-7969-2761)
- Jianfei Hu
- Yongding Wu (ORCID: https://orcid.org/0009-0000-4874-2589)
- Jinpeng Lu
- Xiaoxiao Huang (ORCID: https://orcid.org/0000-0003-1083-2217)
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.drup.2025.101240
- Citations
- 26
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 39.48