Development and validation of a sensitive method to quantify a poorly ionized drug, pocapavir, in C57BL/6 mouse plasma

The validated bioanalytical method is suitably equipped to quantify pocapavir while bolstering preclinical and potential applications for first-in-human (FIH) PK characterizations.

Authors

Renmeng Liu (ORCID: https://orcid.org/0000-0001-7797-0994)
Yurong Lai (ORCID: https://orcid.org/0000-0001-9505-333X)
Ashley Davie
Elaine To (ORCID: https://orcid.org/0000-0001-8556-2130)

Institutions

Gilead Sciences (United States) (US)

Publication Details

Journal: Bioanalysis
Published: 2025-03-19
DOI: https://doi.org/10.1080/17576180.2025.2480533
Primary Topic: Antibiotics Pharmacokinetics and Efficacy
Type: article
Field-Weighted Citation Impact: 0.00

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article

Development and validation of a sensitive method to quantify a poorly ionized drug, pocapavir, in C57BL/6 mouse plasma

Renmeng Liu, Yurong Lai, Ashley Davie, Elaine To

Mar 19, 2025

Bioanalysis

Antibiotics Pharmacokinetics and Efficacy

article

Development and validation of a sensitive method to quantify a poorly ionized drug, pocapavir, in C57BL/6 mouse plasma

Renmeng Liu, Yurong Lai, Ashley Davie, Elaine To

March 19, 2025article en

Abstract

The validated bioanalytical method is suitably equipped to quantify pocapavir while bolstering preclinical and potential applications for first-in-human (FIH) PK characterizations.

BioanalysisVol. 17(6)

Gilead Sciences (United States) (US)

Good health and well-being

Openalex Percentile: Top 93%

Antibiotics Pharmacokinetics and Efficacy

DOI Open Access PDF OpenAlex

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Development and validation of a sensitive method to quantify a poorly ionized drug, pocapavir, in C57BL/6 mouse plasma — Renmeng Liu, Yurong Lai, et al. · Bioanalysis (2025) | TGRS Research Map | TGRS