Phenotypic alterations in peripheral blood B Lymphocytes of patients with Alzheimer's Disease
This study reveals an altered B-lymphocyte phenotype in AD patients, marked by functional and compositional dysregulation. Further research incorporating mechanistic, longitudinal, and functional studies is needed to determine whether these immune perturbations directly contribute to AD pathogenesis or arise as secondary effects of neurodegeneration.
Authors
- Jia Chen (ORCID: https://orcid.org/0000-0002-1672-4607)
- Jin Zhou (ORCID: https://orcid.org/0000-0001-6761-3408)
- Ye‐Ran Wang
- Yan‐Jiang Wang (ORCID: https://orcid.org/0000-0002-6227-6112)
- Zhiqiang Xu (ORCID: https://orcid.org/0000-0002-5536-3293)
- Mengting Wang (ORCID: https://orcid.org/0000-0003-2153-6632)
- Zhang-Cheng Fei
- Xiaoqin Zeng (ORCID: https://orcid.org/0000-0003-3149-6320)
- Xinpeng Li (ORCID: https://orcid.org/0000-0003-1165-4723)
- Gui‐Hua Zeng (ORCID: https://orcid.org/0009-0004-8158-9407)
- Yu-Hui Liu (ORCID: https://orcid.org/0009-0004-7700-3522)
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Daping Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100135
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.82